Holger Prokisch is head of the research group “Genetics of Mitochondrial Disorders” at the Institute of Human Genetic of the Technical University Munich and of the Helmholtz Zentrum München, Germany. He undertook his graduate studies in Germany at the Technical University Hannover. After his postdoctoral training at the Institute for Physiological Chemistry, University of Munich, Dr. Prokisch became head of the Biogenesis of Mitochondria research group at the same institute with Prof. W Neupert before attaining his current position.
His research focus seeks to understand genetic variation in both rare and common disorders leading to mitochondria-related disease. He was very successful in integrating genomic approaches with detailed functional biochemical investigations. By applying next generation sequencing the group has contributed to the discovery of more than 30 novel mitochondrial disease genes and diagnosed more than 400 patients. In his work, Dr. Prokisch undertakes genomic, proteomic, metabolomic, and transcriptomic studies to produce a comprehensive picture of mitochondrial dysfunction. Dr. Prokisch is principle investigator of two subprojects in the German Network for mitochondrial disorders and he is coordinating the E-rare funded European network for mitochondrial disorders GENOMIT.