Pierre-Emmanuel Gleizes is professor of cell biology at the University of Toulouse, France, and group leader at the Center for Integrative Biology (CBI; cbi-toulouse.fr/eng/). His work focuses on the mechanisms of ribosome biogenesis in human cells and the cellular disorders associated with defects in ribosome synthesis. This includes the characterization of new molecular and cellular mechanisms involved in the multiple steps required for preribosomal RNA processing, ribosomal subunit assembly and their intracellular transport. He pioneered the field of ribosomopathies by studying the defects in ribosome synthesis associated with Diamond-Blackfan anemia, a rare congenital bone marrow failure associated with variants in ribosomal protein genes. His group has performed the functional characterization of a large proportion of the ribosomal protein genes associated with this disease through various collaborations in Europe and the USA. He was part of the EuraNet EuroDBA2 project and is currently coordinating the EJPRD 2019 RiboEurope consortium, which aims to identify genes involved in ribosomopathies, in particular rare inherited bone marrow disorders, and to improve the diagnosis of these diseases.