Dr. McKerlie (DVM, DVSc, MRCVS)Â is a Senior Associate Scientist at The Hospital for Sick Children and Professor in the Department of Laboratory Medicine & Pathobiology at the University of Toronto. A Veterinary Pathologist and Phenogenomic Scientist, he is also Director of Research Partnerships at the Toronto Centre for Phenogenomics (TCP) and Staff Scientist with the Samuel Lunenfeld Research Institute of Mount Sinai Hospital.
His research focuses on developing and using mouse models to discover and understand the function of genes that cause disease in children and adults; particularly the comparative pathology and tissue changes related to genetic manipulation in the mouse. Dr. McKerlie is project leader of the NorCOMM2 project, Canadaâ€™s contribution to the International Mouse Phenotyping Consortium (IMPC) that aims to produce and phenotype up to 20,000 mutant mouse lines and make the repository of models and data publically available as a hypothesis-generating resource. The IMPCâ€™s mission is to get its data and resources into the hands of the research community to support their hypothesis-driven research, and generate collaborations where the mouse biology, production, phenotyping, and pre-clinical application knowledge and expertise it has can help. The NorCOMM2 project within the IMPC has established expertise in imaging and pathology-based phenotyping, particularly suited for characterization of embryo & neonatal lethal (congenital) phenotypes for comparative analysis to human disease.
Systematic large-scale gene function analysis of the mouse genome: An opportunity for new mouse models of rare diseases for research and drug discovery